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NF-kappaB-mediated vascular dysfunction in heart failure secondary to chronic streptozotocin diabetes.
As hyperglycemia is known to activate NF-kappaB, in the present study we examined the hypothesis that NF-kappaB overexpression in diabetic rats leads to vascular dysfunction independently of hyperglycemia. After implantation of mini-osmotic pumps to deliver streptozotocin (70 mg/kg) for 4 weeks, rats 50e0806aeb gailhea
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